Locally Advanced Breast Cancer

Locally advanced breast cancer.

The multidisciplinary management of patients with locally advanced breast cancer (LABC) has evolved over the last three decades. The introduction of chemotherapy (CT) and endocrine therapy in conjunction with surgery and radiation therapy (XRT) have changed the natural history of this disease. The authors discuss the role of the taxanes, novel endocrine therapy, and high-dose CT programs in the...

Neoadjuvant chemotherapy for locally advanced breast cancer.

Preoperative systemic therapy is the standard of care in locally advanced breast cancer. In this setting, the intent of preoperative systemic therapy is to expand surgical options and to improve survival. Locally advanced and inflammatory breast cancer have different biological features, but they share the use of preoperative (primary, neoadjuvant) systemic therapy as the initial treatment of c...

Current definition of locally advanced breast cancer.

Management of locally advanced breast cancer.

Multimodality therapy--i.e., surgical excision followed by appropriate systemic therapy and radiotherapy--has an established role in managing patients with locally advanced breast cancer (LABC). Preoperative chemotherapy permits optimal local control with less radical surgical intervention, although its impact on overall survival is still unclear. Definitive data are not yet available to determ...

Radiofrequency thermoablation in locally advanced breast cancer.

The authors report their experience of 8 cases of breast cancer in six patients, treated by radiofrequency thermoablation. Two patients had bilateral breast cancer infiltrating the skin. All patients, but one, were alive at two years follow-up. The age range was 54-75 years old (median, 71 years old). We observed complete regression in one patient, regression with residual scar in two patients ...